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OLD MEN AND BIRTH DEFECTS Risk increases with age: Men over 40-45 have a slightly higher chance of fathering a child with birth defects-especially chromosomal abnormalities, heart defects, and facial or urogenital malformations. Why it happens: As men age, sperm undergo more cell divisions, leading to higher rates of DNA mutations, reduced sperm quality, and age-related genetic or epigenetic changes. Relative vs. absolute risk: The increase is small but measurable-for example, about 10-30% highe
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