Hundreds of aircraft and thousands of servicemembers were involved in the war's launch, the Pentagon's top general said.
The strikes came two days after the latest U.S.-Iran talks as Trump had pressured Tehran for a deal to constrain its nuclear program, building up a fleet of American warships in the region.
Iranian Supreme Leader Ayatollah Ali Khamenei was killed in Israeli airstrikes with U.S. support on Saturday. "Operation Epic Fury" will be "massive and ongoing," President Trump said.