Weill Cornell Medicine researchers have determined the full-length structure of a blood pressure-regulating hormone receptor for the first time, uncovering how it functions, which may enable better ...

Glutamate receptors, including AMPA and NMDA subtypes, are pivotal mediators of excitatory transmission and plasticity across the mammalian central nervous system. Their regulation, which involves ...

Scientists have revealed the molecular structure of a type of receptor that's crucial to brain development and function. 'This study shows the dominant assemblies and states of the GABA receptor. That ...

Explore NMDA receptor modulation and its critical role in neuronal development and cognitive functions like learning and memory.

Researchers have discovered how unstructured segments of surface proteins regulate the biological function of a cell. Their study, published in Nature Communications, sheds new light on the interplay ...

A GPS-like technique has been used to track G protein-coupled receptor movement, revealing how these essential receptors function. Although G protein-coupled receptors (GPCRs) are crucial to the ...

The brain’s cerebellum plays a key role in coordinating movement, balance, and cognition. Injury to the cerebellum can have a profound impact on basic motor skills, such as sitting, standing, and ...

A research team of the University Medical Center Mainz has succeeded in observing for the first time how G protein-coupled receptors in living cells actually respond to activating substances. The ...

Researchers have revealed a previously unknown function of opioid receptors in the development of the enteric nervous system (ENS), often referred to as the 'brain in the gut.' This discovery ...

The collaboration targets disease areas where conventional small molecule drug discovery has faced challenges.